Macular amyloidosis is a pruritic eruption that is variable in severity and consists of small, dusky-brown or grayish pigmented macules. Macular amyloidosis (MA) is the most subtle form of cutaneous amyloidosis, characterized by brownish macules in a rippled pattern, distributed predominantly. CASE REPORT. An unusual presentation of macular amyloidosis. Bárbara Lima Araújo MeloI; Igor Santos CostaII; Clara de Assis Martins GoesIII; Celina Aguiar.

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A Clinico-Epidemiological Study of Macular Amyloidosis from North India

Comparative study of phototherapy UVB vs photochemotherapy PUVA vs topical steroids in the treatment of primary cutaneous lichen amyloidosis.

Frequent association between MEN 2A and cutaneous lichen amyloidosis. Histopathology of primary cutaneous amyloidoses and systemic amyloidosis. Sun exposure did seem to play an important role in the localization of disease. Histopathological findings from the 26 biopsies undertaken and studied are summarized.

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If the condition affects nerves that control blood pressure, you may experience dizziness or near fainting when standing too quickly. Only comments written in English can be processed. Primary localized cutaneous amyloidosis. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.


This is a case of macular amyloidosis with an unusual presentation. Genetic factors in the mcaular diseases.

Primary cutaneous amyloidosis

Nil Conflict of Interest: The mean age of onset was Moreover, sunny weather contributing to increased pigmentation in PLCA has previously been reported. Materials and Methods Fifty patients with a clinical diagnosis of MA attending the out-patient clinic of a tertiary care amilodiosis center were enrolled in the study.

Apoptosis in primary cutaneous amyloidosis. A hyperpigmented, rippled eruption in a Hispanic woman: Straight non branching amyloid filaments with a diameter of 6 – 10 nm showing a hollow core on cross section Infra red microscopy reveals a beta—pleated antiparallel configuration.

Macular Amyloidosis (Friction Amhyloidosis)

Maculae is no convincing explanation for the origin of the amyloid protein in the skin. Courtesy of Bryan Anderson, MD Expected results of diagnostic studies A skin biopsy stained with hematoxylin and eosin typically demonstrates amorphous deposits of eosinophilic material amyloid deposits within the papillary dermis.

Touart DM, Sau P. Treatment of Immunoglobulin Light Chain Amyloidosis: Macular amyloidosis MA is the most subtle form of cutaneous amyloidosis, characterized by brownish macules in a rippled pattern, distributed predominantly over the trunk and extremities.


Epidermis was essentially normal in most of the sections. The use of nylon towels or brushes on the skin has also been described as a risk factor for the development of MA. Failure of etretinate RO in lichen amyloidosus.

Role of friction was inconclusive. All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. Dispenzieri A, et al. Histochemistry and electron microscopy.

Amyloidosis – Symptoms and causes – Mayo Clinic

Macular amyloidosis MA was first described in by Palitz and Peck. In our study, there was a wide variation in the duration of the akiloidosis at the time of presentation 1 month yearsand about half of the patients presented within 2 years of appearance of the lesions. For all other comments, please send your remarks via contact us. The amyloid deposits in macular amyloidosis are keratinocyte-derived.