ABSTRACT. Background: The dengue and chikungunya epidemics have major challenging problems and have become essentially a public health importance. The Chikungunya virus was isolated from mosquitoes and found to be identical to the AV circulating human strain. This is the first field study. Mosquitoes transmit numerous arboviruses including dengue and chikungunya virus (CHIKV). Chikungunya is a re-emerging arthropod-borne.

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Manifestasi Klinis Infeksi Virus Chikungunya Pada Kejadian Luar Biasa Di Indonesia

Chikungunya infection in children. The outbreak initially began in October of and has since spread throughout the western hemisphere, affecting 45 countries and territories and causing approximately 1.

Other measures of initial disease severity during acute disease were not associated with development of chronic disease, including initial viral load, number of joints affected, and duration of hospitalization [ 30 ]. In most cases of CHIKV infection, patients develop symmetric oligo or polyarthralgia within minutes to days following the initial onset of fever [ 91840 ].

Clinical and radiological features of imported chikungunya fever in Chikungunnya However, the value of the more traditional and invasive methods of sampling, including synovial fluid collection and synovial biopsy should still be recognized.

A mean follow-up of two years. The purpose of this review is to evaluate the literature chikunugnya summarize the current state of knowledge regarding CHIKV-associated disease, including clinical presentation, diagnosis, risk factors for development of severe disease, treatment, and pathogenesis in human patients.

By utilizing advanced imaging techniques, particularly MRI, it will be possible to perform a more thorough evaluation of potentially affected joints and associated soft tissues in CHIKV patients with acute disease.

Disease characterized by fever accompanied by pain in the joints of the dominant. While more invasive methods such as synovial fluid samples and synovial biopsies could undoubtedly add significant information to the growing cchikungunya of knowledge on CHIKV pathogenesis, these procedures are not without risk to the patients and may therefore require more substantial justification to be performed in prospective studies.

Majalah Kedokteran Nusantara (Journal of Medical School)

Because of the great variability in the clinical workups available in the literature, it is likely that patients that are currently classified as having chronic CHIKV-associated arthritis actually represent a heterogeneous group of conditions.


In some cases joint pain may resolve, but stiffness remains [ 3 ], perhaps suggesting permanent alterations in articular or peri-articular tissues resulting in decreased mobility.

Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages. In most cases these symptoms will resolve in approximately 2 weeks [ 9 ]. The jurnnal phase of Chikungunya virus infection in humans is associated with strong innate immunity and T CD8 cell activation.

Immunogenicity, safety, and tolerability of a recombinant measles-virus-based chikungunya vaccine: Suspected Chikungunya are interviewed and taken blood. The case numbers decreased inresulting in a total of cases of CHIKV-induced disease and 1 locally acquired case in Texas [ 8 ].

Much of the current literature focuses on the use of standard radiography for evaluation of joints in CHIKV-infected patients and results are often variable [ 924354041 ]. While there have been millions of people affected by CHIKV within the last decade, methods of prevention and treatment are still lacking.

Chikungunya and DHF cases were tended to occur in residential land use which close to the commercial land use. The most joint pain symptom reported is wristand knee joints While patients in this study improved overall, the authors concluded that there was no advantage to use of hydroxychloroquine as compared to NSAIDs or steroids.

This study provides useful information for urban public health management.

Based on the same vector with dengue hemorrhagic fever transmission, an ecological approach using GIS was taken to compare the spatial-temporal pattern between chikungunya kurnal DHF. These initial assessments might also be useful for guiding treatment options in patients.

Email this article Login required. Diagnosis of CHIKV Infection As discussed, the clinical presentation of CHIKV-associated arthralgia during the juurnal stages can be quite similar to other arthritogenic alphaviruses and other tropical arboviruses such as dengue and Zika [ 3945 ].

Manifestasi Klinis Infeksi Virus Chikungunya Pada Kejadian Luar Biasa Di Indonesia – Neliti

Article Tools Print this article. Other similarities in laboratory results shared by CHIKV and RA include variably elevated erythrocyte sedimentation rates, elevated C-reactive protein, and presence of anti-citrullinated protein antibodies [ 9203135384047 ].


It is essential that thorough clinical workups of patients during acute stages be performed to evaluate cihkungunya existing disease. Additionally, many studies have demonstrated persistent IgM levels in patients lasting 18 months or longer [ 2430323641 ].

Emerging viral infections in rheumatic diseases. In a small cohort of ten patients, decreased pain and swelling were reported in most patients [ 64 ]. Replication of virus occurs within the cytoplasm, associated with cytopathic vacuoles formed from rearrangement of host membranes [ 57 ]. How to cite item. Clinical symptoms chikungunua was performed from 28 confirm chikungunya cases based on laboratory result. Additionally, while radiography has been shown to be useful predominantly at the later timepoints as discussed above, in a report utilizing MRI, bone erosions, tenosynovitis, and joint effusions have been demonstrated within the first 1 to 2 months p.

Effectiveness of chloroquine and inflammatory cytokine response in patients with early persistent musculoskeletal pain and arthritis following chikungunya virus infection. In one multivariate model, the 3 variables that were independently associated with chronic CHIKV-associated joint disease were being 45 years old or older, the initial severity cbikungunya joint pain, and underlying osteoarthritis [ 29 ].

Goupil 1 and Christopher N. Additionally, some of jurnsl such as dengue, Zika, and CHIKV are currently co-circulating in the western hemisphere [ 39 ], thus care should be taken to definitively identify the cause in any case with this presentation.

Location of cases was obtained using GPS. Jurnal Biotek Medisiana Indonesia. Because the acute presentation of CHIKV-associated disease as visualized by MRI is currently unknown, it is possible that scans performed at early junral will provide only minimal information in regard to disease status, or that the acute presentation will be variable among patients and therefore the interpretation jhrnal results challenging.

In cases refractory to NSAID treatment, short-term courses of corticosteroids have been attempted with variable success. Chikungunya is a re-emerging disease that caused byalphavirus family Togaviridae.