Follicular mucinosis is a term that encompasses three related entities. Alopecia mucinosa, Urticaria-like follicular mucinosis, and cutaneous lymphoma related. On hair-bearing skin (e.g. scalp), overlying alopecia is notable, hence the term “ alopecia mucinosa” (see Figure 5). Plaques are often composed of densely. Alopecia mucinosa is a skin disorder that generally presents, but not exclusively, as erythematous plaques or flat patches without hair primarily on the scalp.

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A detailed morphologic and immunopathologic study. Infobox medical condition new All stub articles. Department of Dermatology, P. Report of four cases not responsive to minocycline. Discontinue therapy or consider slow titration over months or years after complete response is evident.

It may be due to dysfunctional T cells inducing mucin production by fibroblasts surrounding follicular epithelium, or due to excess production of mucin by follicular keratinocytes. Long-term dermatologic follow up is necessary; a reasonable frequency for alopecua and lymph node exam is every months initially, then annually.

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Pathology Outlines – Alopecia mucinosa

Intralesional corticosteroids—triamcinolone acetonide, 2. Click here for patient related inquiries. Mycosis fungoides associated follicular mucinosis on posterior scalp. Characteristic findings on physical examination Lesions are often asymptomatic but may itch or burn; they develop over weeks or months not days. The biopsy sections showed accumulation of mucin in all follicles in the sections and a fairly dense lymphocytic infiltrate with several eosinophils.


In this article we describe three cases, two children with a single facial lesion clinically suspected to be leprosy in whom biopsy showed follicular mucinosis without granulomas. By registering you consent to the collection and use of your information to provide the products and services you have requested from us and as described in our privacy policy and terms and conditions. Fitzpatrick’s Dermatology in General Medicine. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment.

A year-old boy presented in Septemberwith a hypopigmented and hypoaesthetic shiny patch on the left cheek of few months duration. We have not been able to find any reported case of Alopecia mucinosa treated with dapsone alone. Treatment based on single case series of six patients. Minocycline mg orally, twice daily; response noted within 6 months; begin to taper slowly over months after lesions have cleared.

Therapeutic options and efficacy are based on retrospective case series or anecdotal reports; no controlled trials exist. Based on clinical suspicion both were started on multi drug therapy MDT for leprosy with complete resolution of the lesions.

Follicular Mucinosis (Alopecia Mucinosa)

Inflammatory diseases of hair mucinpsa, sweat glands and cartilage; pp. It is common practice that in regions endemic for leprosy, such as India, children and young adults who present with single hypoesthetic lesions on the face are not biopsied but treated on clinical suspicion alone and because they respond to MDT would be labeled as leprosy.


Sensations were mildly impaired over the site but no thickened nerve was palpable. Disorders of skin appendages L60—L75— Support Center Support Center.

While response to dapsone in the first six cases and minocycline in the last case is possible, the most consistent common factor in all cases seems to be antileprosy treatment. This hair loss is reversible in the early stages, but once the disease advances, the hair follicles are mufinosa, and Scarring alopecia occurs.

The etiology is not known. And are there other choices? Lever’s Histopathology of the skin.

Isotretinoin is pregnancy category X. Single lesion Alopecia mucinosa in children and young adults responds rapidly and completely with antileprosy treatment. Who is at Risk for Developing this Disease? No reliable distinguishing clinical, histological, or molecular parameter exists. Routine laboratory monitoring is suggested i.

A reaction pattern in follicular epithelium.

Because there is a small chance of spontaneous resolution for other forms of the disease, the effect of treatment can be difficult to assess.