Mar 1, Aquasomes are spherical 60– nm particles used for drug and antigen delivery. Aquasomes discovery comprises a principle from. Sep 6, Aquasomes are spherical 60– nm particles used for drug and antigen delivery. Aquasomes discovery comprises a principle from. Mar 13, PDF | Aquasomes are three-layered ceramic core based carbohydrate coated nanoparticle delivery systems with bioactive molecules adsorbed.
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Aquasome technology represents a patform system for conformational integrality and biochemical stability of bioactives. Three types of core materials are mainly used for producing aquasomes: It is widely used for the preparation of implants for drug delivery.
Aquasomes discovery comprises a principle from microbiology, food chemistry, biophysics and many discoveries including solid phase synthesis, supramolecular chemistry, molecular shape change and self assembly. Their large sized and active surfaces enable them to be loaded with water insoluble drugs through non covalent processes. The solid core provides the structural stability, while the carbohydrate coating protects against dehydration and stabilizes the biochemically active molecules.
Nanobiopharmaceutics involves delivery of biopharmaceutical product through different biomaterials like multifunctional nanoparticles, quantum dots, aquasomes, superparamagnetic iron oxide crystals, and liposomes dendrimers. Department of Pharmacology, K.
This article discusses the problems faced in the delivery of clinically important peptides and presents aquasomes as a reliable approach to troubleshoot them. This property of maintaining the conformational integrity of bioactive molecules has led to the proposal that aquasomes have potential as a carrier system for delivery of peptide-based pharmaceuticals. Aquasomes are one of the most recently developed delivery systems that are finding a velivery as peptide and protein carriers. The solid core provides the structural stability, while the carbohydrate coating protects against dehydration and stabilizes the biochemically active molecules.
This property of maintaining the conformational integrity of bioactive molecules has led to the proposal that aquasomes have potential as a carrier system for delivery of peptide, protein, hormones, antigens and genes to specific sites.
Aquasome deliver their content through specific targeting, molecular sheiling and slow sustained release process. Aquasomes are nanoparticulate carrier system but instead of being simple nanoparticles these arse three layered self assembled structures, comprised drgu a solid phase nanocrystalline core coated with oligomeric film to which biochemically active molecules are adsorbed with or without modification.
The brushite is unstable and converts to hydroxyapatite upon prolong storage. Their intended route of administration is parenteral and with advancement of research in this field, deliery routes might be contemplated.
Article Information Sr No: Nanotechnology has emerged fields of biomedical research in the last few decades the presents context is an attempt to present the brief information about nanobiotechnological applications.
Hydroxyapatite seems, therefore, a better core for the preparation of aquasomes.
Oral delivery of enzymes like serratiopeptidase has also been achieved. Aquasomes are spherical 60— nm particles used for drug and antigen delivery. The delivery system has been successfully utilized for the delivery of insulin, hemoglobin, and various antigens.
Aquasomes: a promising carrier for peptides and protein delivery.
Calcium phosphate is the core of interest, owing to its natural presence in the body. They comprise a central solid nanocrystalline core coated with polyhydroxy oligomers onto which biochemically active molecules are adsorbed.
This article reviews the principles of self assembly, the challenges of maintaining both the conformational integrity and biochemical activity of immobilized surface pairs, and the convergence of these principles into a single functional composition. These are nanoparticulate carrier systems with three-layered self-assembled structures.