Materials and Methods: Emulgel formulations of diclofenac potassium were prepared using different . subjected to various evaluation parameters such as drug. Emulgels have been extensively covered as a promising drug delivery system for the administration of lipophilic drugs. This work was. Formulation and Evaluation of Luliconazole Emulgel for. Topical Drug Delivery. Dhobale Shankar,* Shelke Gajanan, Jadhav Suresh, Gaikwad.
|Published (Last):||25 April 2010|
|PDF File Size:||10.20 Mb|
|ePub File Size:||10.32 Mb|
|Price:||Free* [*Free Regsitration Required]|
You can cite all versions by using the DOI Moreover, the effectiveness of the formulation in delivering the drug as manifested in vitro emulgell ex vivo studies, was transposed into significantly mitigating inflammation in animal models.
Formulation and Evaluation of Tioconazole Emulgel for Topical Drug Delivery System
Within 24 hrs from the Submission of Papers Review Notification: Species-dependent metabolism and newer paradigm shift from oral to non-oral delivery.
The total duration of this study was approximately 5 months considering conceptualization to completion of animal studies. These are applied as wide spectrum of preparations in case of both cosmetic and dermatological, to the healthy or diseased skin. Hence, the formulation strategy for aceclofenac and thereby, an efficient drug delivery led od an evalhation anti-inflammatory activity.
The study was initiated in December, and completed in May, Formulation and evaluation of aceclofenac topical emulgel. In vitro diffusion studies were done with the help of modified Franz diffusion cell Sumati sales corporation, Mumbai, India. Secondly, relevance of this fact is even more when the respective drugs are taken life-long in chronic conditions like arthritis.
The animal studies were conducted in the animal house, under appropriate care and precautions. The highest drug release was observed with T4, where the drug release showed The solubility of aceclofenac in different oils, surfactants and co-surfactants was determined since it is the most important criteria for microemulsion preparation Table 2. Thus, the formulated emulgel was considered optimum, based on the pharmaceutical characteristics and further subjected to animal testing for anti-inflammatory activity using two animal models viz.
There was a problem providing the content you requested
Clindamycin emulgel, Formulation, Evaluation. Topical drug administration is simplest and easiest route of localized drug delivery anywhere in the body by routes as ophthalmic, evaluatino, vaginal and skin. Ointments, Creams and Gels.
Absorbance was measured after suitable dilution at nm using UV-Vis spectrophotometer. The drug release was ans to be The trend in inflammation and reduction was similar as observed with the first model, in the respective groups. The particle size of the microemulsion was found to be No allergic symptoms like inflammation, redness, irritation appeared on rats up to 24 h. After a number of trials, microemulsion of aceclofenac was optimized with: So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.
The prepared emulgels were evaluated for physical appearance, pH, drug content, In-vitro diffusion studies, microbiological assay and skin irritation test.
FORMULATION AND EVALUATION OF CLINDAMYCIN PHOSPHATE EMULGEL
However, these differences were not statistically significant. Elsadig Gasoom FadelAlla Elbashir. February 21, ; Accepted: Dr Ashok Kumar Verma.
Both of these models differ in terms of underlying pathways of the inflammatory cascade. The microemulsion region obtained in 1: Polysorbate 80, isopropyl myristate, was procured from Molychem Mumbai, India and Loba chemie pvt limited, Mumbai, Indiarespectively.
An emergent tool in topical drug delivery. Particles size and zeta potential: However, further research is warranted focusing on formulation stability and more in vivo studies to substantiate the potential of the emulgel formulation as robust and efficacious topical based drug delivery system of aceclofenac.
Similar Articles in this Journal. Percentage inflammation was calculated as under:. The study also highlights preclinical analysis, that aceclofenac and diclofenac show equal efficacy when used topically.
Although, the pharmacological evidence presented herein, shows a quantitatively higher activity for the marketed preparation, the designed formulation was at par with the marketed one with significantly better activity demonstrated against the placebo. It is usually used to treat infections with anaerobic bacteria, but can also be used to treat some protozoal diseases, such as malaria.
The aim of present study was to develop an emulgel formulation of clindamycin phosphate using Carbopol or HPMC as a gelling agent. Emulgel is one of the emerging topical drug delivery system for the delivery of hydrophobic drugs which overcome various disadvantages of ointments and creams such as greasiness and phase inversion. Herein, no further evaluation and animal studies were done to assess the implications of the formulation in vivo.
Microemulsion formulation aids in improving the drug solubility owing to reduced particle size, improved surface tension and better permeation. The present work is to develop Clindamycin emulgel adaptable topical drug delivery systems which provide protection against oxidation, fast absorption, prolonged release and enables reduction in dose and evaluate the emulgel using an ideal topical drug candidate of Clindamycin by suitable method with its release.
FORMULATION AND EVALUATION OF CLINDAMYCIN PHOSPHATE EMULGEL | Zenodo
Pharmaceutical Sciences Encyclopedia, Gad, S. Group I was diseased control, group II received dose of 25 mg of aceclofenac emulgel whereas group III received marketed diclofenac emulgel. The activity produced by the formulated emulgel was at par with the most marketed emulgel formulation.