The nucleus accumbens (NAc or NAcc), also known as the accumbens nucleus, or formerly as basolateral amygdala, ventral hippocampus, thalamic nuclei ( specifically the midline thalamic nuclei and intralaminar nuclei of the thalamus). The ventral anterior cingulate cortex includes subcallosal and precallosal portions that have extensive connections with the insula, prefrontal cortex, amygdala. Limbic System Panji Fakhruzzaman Teknik Elektro Amygdala Fungsi Amygdala Limbic System Sistem Limbik 1. Memegang.

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Nucleus accumbens

Chronic stress induced changes in BDNF expression profile is normalized to respective control level. However, although they are phenotypically equal to their dorsal counterparts, they have some differences in terms of connectivity. The ventral striatum and dorsal striatum collectively form the striatumwhich is the main component of the basal ganglia. Serum corticosterone level was determined by using Correlate – EIA kit according to the manufacturer’s instructions Assay designs.

Stress increases brain-derived neurotropic factor messenger ribonucleic acid in the hypothalamus and pituitary. Table 1 Summary of body weight measures. P-values less than 0.

Nucleus accumbens – Wikipedia

The output of sense organs is first received by the thalamus. Neurotrophins and synaptic plasticity. The upregulation of BDNF reported earlier in the hypothalamic paraventricular nucleus occurs in response to both single 2 h as well as chronic 7 days of immobilization stress [19]. Furthermore, a single session of acute immobilization stress AIS, 2h leads to a significant increase in spine density 10 days, but not 1 day, later in the BLA.

The nucleus accumbens core NAcc core is the inner substructure of the nucleus accumbens. Dopaminergic pathways Mesocortical pathway: Sexual behavior is highly rewarding Tenk et al.


The number of mating-induced c-Fos-IR cells was significantly decreased in sexually experienced animals compared to sexually naive controls.

Such effects suggest that specific motivational states gate the arousing effects of Pavlovian incentives processes on instrumental performance Amygdala hijack is a term coined by Daniel Goleman in his book Emotional Intelligence: Here, we show that chemogenetic or optogenetic activation of excitatory adenosine A2A receptor-expressing indirect pathway neurons in the core region of the NAc strongly induces slow-wave sleep.

Dopamine neurons in the VTA are activated by food and water, and dopamine release in the NAc is stimulated by the presence of natural reinforcers, such as food, water, or a sexual partner. Author information Article notes Copyright and License information Disclaimer.

The nucleus accumbens is one of the few regions that receive histaminergic projections from the tuberomammillary nucleus the sole source of histamine neurons in the brain. Behavioral findings are supported by evidence that distinct neural circuits centered on the NAc core and shell mediate the general and specific forms of transfer, respectively, and ongoing work is beginning to explain how Pavlovian and instrumental learning processes that occur independently and at separate times are integrated within neural circuits that govern behavioral control.

Amygdala hijack

Thus for example ‘one key marital competence is for partners to learn to soothe their own distressed feelings Eight week-old adult male Wistar rats National Centre for Biological Sciences, Bangalore, India were housed in groups of 2 or 3 in a standard 14 h light and 10 h dark schedule lights on at 7: Substantia innominata Nucleus basalis Nucleus of diagonal band. Drugs of abuse induce neuroplasticity in the natural reward pathway, specifically the nucleus accumbens NActhereby causing development and expression of addictive behavior.


Altered striatal dopamine signaling.

Lay summary — Cell Press 18 July Therefore, in the present study we test the prediction that if BDNF plays a key role in stress-induced structural plasticity across both hippocampus and amygdala, then the divergent effects of fungxi should also be manifested as differential patterns of BDNF expression in these two brain areas. This implies that signaling mechanisms more downstream of the initial changes in glucocorticoids and glutamate, but upstream of BDNF, may hold the key to the differential impact of stress in these brain areas.

First, we measured, 1 day after the end of the 10 day CIS protocol, the blood serum levels of corticosterone, a common indicator of HPA axis activation.

Areas that receive especially dense projections include the cerebral cortex, hippocampus, neostriatum, nucleus accumbens, amygdala, and hypothalamus. The nucleus accumbens core is involved in the cognitive processing of motor function related to reward and reinforcement and the regulation of slow-wave sleep. In contrast to the robust effects seen when the 2 h immobilization stress is repeated for 10 consecutive days, only a single episode of the same stress acute immobilization stress or AIS is known to trigger a different temporal pattern of changes in the BLA.

These findings, in turn, are consistent with amygadla significant body of evidence establishing a role for BDNF as a potent regulator of morphological plasticity of dendrites in various brain regions [17].