INTRATUMOR HETEROGENEITY AND BRANCHED EVOLUTION REVEALED BY MULTIREGION SEQUENCING PDF

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing. / Gerlinger, Marco; Rowan, Andrew J.; Horswell, Stuart; Larkin, James;. Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion . intratumor heterogeneity, we performed exome sequencing, chromosome. Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing N Engl J Med ;–92Re: Single-cell Exome Sequencing Reveals.

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To examine intratumor heterogeneity, we performed exome sequencing, chromosome aberration analysis, and ploidy profiling on multiple spatially separated samples obtained from primary renal carcinomas and associated metastatic sites.

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing – DTU Orbit

F reserves the right to monitor all Material and to remove any Material which it considers in its absolute discretion to be unlawful, inappropriate, offensive or otherwise in breach of these Terms and Conditions. Andrew ; Swanton, Heterogenrity. Register Already registered with FPrime? Allelic composition and ploidy profiling analysis revealed extensive intratumor heterogeneity, with 26 of 30 tumor samples from four tumors harboring divergent allelic-imbalance profiles and with ploidy heterogeneity in two of four tumors.

Intratumor heterogeneity can lead to underestimation of the tumor genomics landscape portrayed from single tumor-biopsy samples and may present major challenges to personalized-medicine and biomarker development.

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Provide sufficient details of any financial or non-financial competing interests to enable users to multiregiion whether your comments might lead a reasonable person to question your impartiality. Allelic composition and ploidy profiling analysis revealed extensive revesled heterogeneity, with 26 of 30 tumor samples from four tumors harboring divergent allelic-imbalance profiles and with ploidy heterogeneity in two of four tumors.

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Intratumor heterogeneity was observed for a mutation within an autoinhibitory domain evo,ution the mammalian target of rapamycin mTOR kinase, correlating with S6 and 4EBP phosphorylation in vivo and constitutive activation of mTOR kinase activity in vitro. By posting or uploading Material you warrant and represent that: Heteogeneity Policy Provide sufficient details of any financial or non-financial competing interests to enable users to assess whether your comments might lead a reasonable person to question your impartiality.

Classified evolutoin close New Finding 7. View graph of relations. F does not screen, edit, publish or review Material prior to its appearance on the website and is not responsible for it. FPrime is an expert-curated resource to help you find the articles of greatest interest and relevance to you. Examples of ‘Financial Competing Interests’ You expect to receive, or in the past 4 years have received, any of the following from any commercial organization that may gain financially from your submission: Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples.

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An analysis of natural T cell responses to sequecing tumor neoepitopes [Front Immunol, 8,] doi: A comment on this article appears in ” Words of wisdom. Or filter your current search. We characterized the consequences of intratumor heterogeneity using immunohistochemical analysis, mutation functional analysis, and profiling of messenger RNA expression. The New England Journal of Medicine. Neither of the above. Funded by the Medical Research Council and others.

Mutational intratumor heterogeneity was seen for multiple tumor-suppressor genes converging on loss of function; SETD2, PTEN, and KDM5C underwent multiple distinct and spatially separated inactivating mutations within a single tumor, suggesting convergent phenotypic evolution.

See N Engl J Med. Either your web browser doesn’t support Javascript or it is currently turned off. Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples.

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Material does not reflect the views or opinions of F, its agents or affiliates. METHODSTo examine intratumor heterogeneity, we performed exome sequencing, chromosome aberration analysis, and ploidy profiling on multiple spatially separated samples obtained from primary renal carcinomas and associated metastatic sites.

A comment on this article appears in ” Kidney cancer: Hranched summary of the content will be automatically included. Recommend to your librarian.

Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.

Intratumor heterogeneity was observed for a mutation within an autoinhibitory domain of the mammalian target of rapamycin mTOR kinase, correlating with S6 and 4EBP phosphorylation in vivo and constitutive activation of mTOR kinase activity in vitro. Recommendations Abstract Comments You have reached your article limit.

A comment on this article appears in ” Impact of intra-individual molecular heterogeneity in personalized treatment of hepatocellular carcinoma. Chemotherapy treatment is associated with altered PD-L1 expression in lung cancer patients Research output: Intratumor heterogeneity can lead to underestimation of the tumor genomics landscape portrayed from single tumor-biopsy samples and may present major challenges to personalized-medicine and biomarker development.

Mutational intratumor heterogeneity was seen for multiple tumor-suppressor genes converging on loss of function; SETD2, PTEN, and KDM5C underwent multiple distinct and spatially separated inactivating mutations within a single tumor, suggesting convergent phenotypic evolution. Mutational intratumor heterogeneity was seen for multiple tumor-suppressor genes converging on loss of function; SETD2, PTEN, and KDM5C underwent multiple distinct and sequecing separated inactivating mutations within a single tumor, suggesting convergent phenotypic evolution.

The New England Journal of Medicine.