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Gene Ontology GO Terms. The relative expression of osteogenic and bone resorption markers was determined by real-time polymerase chain reaction and Western blotting, respectively.
Abstract Ginkgo biloba, an herbal medication, is capable of lowering glucose, fat, and lipid peroxide in diabetic patients. No matching affiliation detected. In the current study, we tested the hypothesis that Ginkgo biloba extract GBE prevented hyperinsulinism-induced glucose intolerance in hepatocytes.
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Here, we uncovered the therapeutic effect of morin against osteoporosis and demonstrated its suppressive action on the MAPK pathway in this disease. Journal of Natural Medicines [24 Jul72 4: Body weight was regularly monitored. Gene Ontology GO Terms. How does Europe PMC derive its citations network?
Body mineral density BMD was determined at proximal femurs using dual energy X-ray absorptiometry.
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Morin treatment also increased the number of trabecular bones in DEX-induced rats. Mechanistically, morin reversed the decrease of osteogenic markers and increase of bone resorption markers, which might eventually be mediated by modulation of MAPK signaling cascades. To better show its efficacy, we included a control group that was treated with rosiglitazone, a type of thiazolidinedione 11481. Body weight and BMD were both significantly decreased in osteoporotic rats, although BMD was partially restored by intraperitoneal morin administration.
Our data suggest that GBE has the potential to prevent insulin resistance and is a promising anti-diabetic drug.