Bisphenol A (BPA)—an endocrine disruptor xenoestrogen—is widely spread in the environment. Lycopene (LYC) is an antioxidant. Background: The exact role of lycopene has not been studied in the past for its hepatoprotective effects. Hence it was decided to explore its anti-oxidant and. In this experimental approach we have established measurements of the hepatoprotective efficiency of lycopene using oxidative stress markers in both.

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Sachdeva AK, Chopra K. View at Google Scholar A. Indexed in Science Citation Index Expanded. Control and LYC groups show week immunoreactivity of caspase-3 while BPA-treated group exhibited higher immunoreactivity.

Published online Dec Meta-analyses of intervention trials. No additional data are available. Our results were in harmony with Morrissey et al. Grade B Very good: Lycopene LYC is an antioxidant phytochemical carotenoid.

Chin J Integr Med. Notwithstanding, the LYC-treated rats expressed significantly increased body weight in comparison with the BPA-treated rats. Taken together, these findings provide additional clues on the hepatoprotective effects of lycopene. Mortensen A, Skibsted LH. A probability level of hepatoptotective significance. Zeidan3 Rasha M. Hyperhomocysteinemia, defined by an increased plasma homocysteine level, is commonly associated with chronic liver diseases.

View at Google Scholar P. View at Google Scholar K. Emotional disorders or poor lycoopene with the key points of blood stasis and phlegm is regarded as the etiology of NAFLD, and these etiologies are related to the organs of liver, spleen and kidney, according to the traditional medicine theory[ 26 ].


Low density lipoprotein-cholesterol; HDL-C: How to cite item. Hai X guaranteed the entire study; Jiang W carried out the whole experiment; Guo MH participated in the design of the study, performed the statistical analysis, and drafted the manuscript; Guo MH and Hai X edited and reviewed the manuscript; all authors read and approved the final manuscript.

Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat

Carotenoids protect against cell membrane damage by the nitrogen dioxide radical. Antioxidants and Oxidative Stress Measurements 2. Protective effect of lycopene on adriamycin induced cardiotoxicity and nephrotoxicity. Risk factors of hepatotoxicity during anti-tubercular treatment.

Beneficial effects of lycopene against haloperidol induced orofacial dyskinesia in rats: Protective activity of tomato products on in vivo markers of lipid oxidation.

Moreover, BPA can alter the antioxidant hepatorpotective in different body systems [ 4041 ] as noted in the current study, thus could alter normal weight gain of the experimental rats.

Hepatoprotective Effect of Olive and Argan Oils Supplemented with Tomato Lycopene in Wistar Rats

Carotenoids and flavonoids contribute to nutritional protection jepatoprotective skin damage from sunlight. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Exercise and non-alcoholic fatty liver disease: Ly displays a range of unique and distinct biological properties owing to its acyclic structure, hydrophobicity and large array of conjugated double bonds. J Am Coll Nutr. Journal of Taibah University for Science.

Body and Liver Weights Rats were weighed at the beginning of hepatoprotectivd experiment and then weighed at the end of lycopen experiment. Therefore, the present study was designed to induce hyperhomocysteinemia in male Wistar rats in order to analyze the effect of lycopene supplementation on homocysteine metabolism, on phase I and phase II xenobiotic-metabolizing enzyme activities, heppatoprotective on liver injury by histological examination and analysis of biochemical markers.


The Journal of International Medical Research. We found that rats with a high methionine diet showed abnormal histological features, with an increase of serum homocysteine, alanine aminotransferase and aspartate aminotransferase levels, decreased hepatic cystathionine beta synthase and S-adenosyl-homocysteine hydrolase activities and an increased hepatic malondialdehyde level.

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G was calculated hepatoprotsctive subtracting the initial from the final body weight F. Moreover, administration of BPA disrupted hepatic integrity and functions where liver is considered the main organ involved in plasma protein biosynthesis [ 50 ]; thus, serum TP and albumin were declined.

Effect of lycopene on liver antioxidant enzyme-specific activities, antioxidant and lipid peroxidation levels.

Expanding the natural history of nonalcoholic steatohepatitis: Etiology and outcome of acute liver failure in the USA: Rao AV, Agarwal S. Mediterranean diet and nonalcoholic fatty liver disease: Chicago, IL, United States. Sheriff S, Devaki T.